027 Myelin basic protein antibodies as a biomarker in morphea
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چکیده
منابع مشابه
Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker
Objective: Multiple sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As myelin basic protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva as a suitable biomarker for detecting MS. Methods: A case-control study was performed in 29 health...
متن کاملutility of myelin basic protein as an early prognostic biomarker in multiple sclerosis
conclusions molecular assays in the early stages of the disease could help in elucidating the effectiveness of the mbp as a prognostic factor in ms. methods this study is convergence of three arms including in silico and in vitro (bioinformatics) with the in vivo (experimental). a novel methodology combining molecular techniques was used to confirm the antigenic properties of mbp and study its ...
متن کاملCerebrospinal fluid myelin basic protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation.
BACKGROUND Release of myelin basic protein (MBP) into the cerebrospinal fluid (CSF) is associated with active demyelination and correlates with outcome in various neurological diseases. HYPOTHESIS/OBJECTIVES To describe associations among CSF MBP concentration, initial neurological dysfunction, and long-term ambulatory outcome in dogs with acute thoracolumbar intervertebral disk herniation (I...
متن کاملMyelin basic protein.
The fact that central nerve tissue is encephalitogenic has been known since the observation of a post-injection reaction of some rabies victims to the Pasteur vaccine that contained nerve tissue (Brostoff, 1977). Subsequently the encephalitogenic agent in central nerve tissue was traced to a component of the myelin sheath, and a protein was finally isolated that in the presence of complete Freu...
متن کاملPhosphorylation of myelin basic protein.
Myelin membranes prepared from rat brain possess both the enzyme and substrates to incorporate azP from (ya2P]ATP into membrane protein constituents. Qf the myelin polypeptides, only the two basic proteins were phosphorylated ; and both components appeared to be equally good substrates for endogenous or added protein kinases. The a2P was transferred primarily to serine residues of the basic pro...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2018
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.03.031